Spatiotemporal single-cell roadmap of human skin wound healing
To infer the differences in epidermal cell trajectories between intact skin and wound conditions, we separated all keratinocytes into wound and non-wound cells using a Gaussian mixture model (GMM) in the ''scikit-learn'' Python package. 124 We first filtered out cells that did not express KRT6A, a strong marker of wound-induced cells. 30, 31 The positive cells